Genital blisters or ulcers
Active vesicles or ulcers may need lesion HSV PCR/NAAT and syphilis evaluation. HSV IgM is not recommended; type-specific HSV serology has selected uses and important limitations.
Genital herpes guide →Diagnosed with genital warts, herpes, syphilis, gonorrhoea or another STI? Finding one STI should prompt assessment for others. HIV, syphilis, hepatitis B/C, chlamydia and gonorrhoea can sometimes be present without obvious symptoms.
Dr Neeraj Garg · MBBS (IMS-BHU), MD (IMS-BHU) · Dalanwala, Dehradun
Clinically planned testing, matched to your exposure and medical history.
A person with genital warts or herpes may also have another STI acquired at a different time or from the same exposure. HIV, syphilis, hepatitis infections, chlamydia and gonorrhoea can be asymptomatic. Diagnosing one infection should lead to a conversation about screening for other treatable or consequential infections—even if there is no discharge, ulcer, fever or pain.
The aim is a comprehensive STI assessment: offer relevant screening, discuss the rationale, and choose the right samples and repeat-testing times. There is no single universal laboratory panel that detects every STI.
These are important screening considerations after an STI diagnosis or concerning sexual exposure. The final tests depend on risk, prior results, vaccination, symptoms and exposure sites.
| Infection | Test commonly used | Sample / key point |
|---|---|---|
| HIV-1/2 | Laboratory fourth-generation HIV-1/2 antigen/antibody test; HIV RNA for selected situations | Blood. Very recent exposure may require follow-up testing; HIV PEP decisions are time-critical. |
| Syphilis | Non-treponemal RPR/VDRL with a treponemal test such as TPHA/TPPA, interpreted together | Blood. One test alone may not establish stage or distinguish treated from active infection. |
| Hepatitis B | HBsAg; anti-HBs and anti-HBc when useful for full infection/immunity assessment | Blood. Vaccination status and post-exposure prophylaxis needs matter. |
| Hepatitis C | Anti-HCV with confirmatory HCV RNA when indicated | Blood. RNA may be considered for selected recent exposures or positive antibody results. |
| Chlamydia | Nucleic acid amplification test (NAAT) | First-catch urine or genital swab; rectal swab when exposure warrants. |
| Gonorrhoea | NAAT; culture and susceptibility when clinically appropriate | First-catch urine or genital swab; throat or rectal swab according to exposure. |
Active vesicles or ulcers may need lesion HSV PCR/NAAT and syphilis evaluation. HSV IgM is not recommended; type-specific HSV serology has selected uses and important limitations.
Genital herpes guide →HPV-related warts are usually diagnosed through clinical examination. A routine HPV blood test cannot determine whether genital warts are present. Other STI screening should still be discussed.
Genital warts guide →Testing for Trichomonas vaginalis or other causes may be indicated. Mycoplasma genitalium testing is generally reserved for particular persistent or recurrent syndromes, not routine testing in everyone.
Chlamydia guide →The recommended timing, urgency and test selection can differ. Partners may need evaluation, vaccination or treatment, and some infections warrant testing again after treatment.
STD specialist guide →Discuss the date and type of contact, symptoms, vaccination history and any earlier STI treatment. Baseline tests help establish current status but may not detect very recent infections.
HIV, syphilis and viral hepatitis tests have different window periods; a clinician may schedule follow-up tests based on the assay and exposure date. NAAT timing also matters.
Positive results need confirmation or interpretation when indicated, appropriate treatment, partner evaluation, counselling, immunisation and sometimes recommended retesting.
An STI test result is more useful when understood alongside symptoms, past reports, previous treatment, possible exposure and test timing. A positive result does not necessarily reveal when or from whom an infection was acquired. Results should be explained without assumptions or judgment. Relevant laboratory tests can be arranged or reviewed as part of clinical care; this page does not advertise a fixed-price laboratory package or promise that all tests are performed on-site.
Yes. A diagnosis of one STI should prompt an assessment for possible coexisting, sometimes symptom-free infections. HIV and syphilis testing are important considerations; hepatitis B and C and chlamydia/gonorrhoea screening depend on history, risk and the exposure sites involved.
No. No single blood panel detects all STIs. Some infections require urine or swab NAATs, lesion testing or examination. Some tests are not useful without symptoms or risk factors.
Not reliably. Chlamydia and gonorrhoea can occur in the throat or rectum without appearing on a urine test. Throat or rectal swabs may be recommended based on reported exposure.
Not necessarily. Many tests have a window period after infection. A doctor may recommend testing now and again later, depending on the exposure and type of test.
Routine HSV IgM is not recommended, and there is no general-purpose HPV blood test for diagnosing genital warts. Active sores may need HSV PCR swabs, while genital warts are often diagnosed on examination.
Seek urgent medical assessment immediately for HIV post-exposure prophylaxis (PEP). Do not wait for a routine STD appointment or for the initial test results.
Clinical reference: CDC STI/HIV Risk Assessment · CDC STI Screening Recommendations · CDC Genital Herpes Guidance.
Confidential STD / STI assessment with Dr Neeraj Garg · MBBS (IMS-BHU), MD (IMS-BHU), at Maheshwari Hospital, Dalanwala, Dehradun.
Medical education only. Investigation and treatment must be individualised; the consultation fee is ₹800. For emergencies, seek urgent medical care.